Trps1 breast
WebTRPS1 gene was responsible for most of the TRPS phenotype; Data show that co-silencing of tricho-rhino-phalangeal-syndrome (TRPS1) and cathepsin D (Cath-D) in breast cancer … WebNov 11, 2024 · In this study, overexpression of lncRNA178030.2 significantly attenuated the inhibitory effect of 1 μM paclitaxel in cell proliferation of MDA-MB-231, while knockdown of lncRNA178030.2 had an opposite effect, suggesting that lncRNA178030.2 mediated the process of paclitaxel resistance of breast cancer cells. TRPS1 is a newly discovered …
Trps1 breast
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WebJun 14, 2011 · Consistent with this, lower abundance of TRPS1 is a poor prognostic marker in breast cancer . The defects associated with TRPS1 mutation ( 31 ) are indicative of a … WebJul 3, 2024 · The GATA transcription factor TRPS1 is abnormally up-regulated in breast cancer, osteosarcoma, prostate cancer, and other tumor tissues, and is instrumental in …
WebJun 14, 2011 · The transcription factor FOSL1 (also known as Fra-1), which is found in basal-like breast cancers but not in the luminal subtype, stimulated the transcription of miR-221/222, and the abundance of these miRNAs decreased with inhibition of the epidermal growth factor receptor (EGFR) or MEK (mitogen-activated or extracellular …
WebTRPS1 is commonly amplified in breast cancer, which suggests that restrained YAP activity favours tumour growth. High TRPS1 activity is associated with decreased YAP activity and leads to decreased frequency of tumour-infiltrating immune cells. Our study uncovers TRPS1 as an epigenetic regulator of YAP activity in breast cancer. WebIn the current study, through TCGA data mining we identified trichorhinophalangeal syndrome type 1 (TRPS1) as a specific gene for breast carcinoma across 31 solid tumor types. Moreover, high mRNA level of TRPS1 was found in all four subtypes of breast carcinoma including ER/PR-positive luminal A and B types, HER2-positive type, and basal …
WebExpression of TRPS1 (GC79, LGCR) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. ... Moderate to strong nuclear positivity was observed in all breast cancers and several cases of ovarian, lung, skin and cervical cancer. Most remaining cancer tissues showed weak cytoplasmic positivity or ...
WebThe association between YAP1 and TRPS1 was primarily clarified by Elster et al, who suggested that YAP1 was downregulated, while TRPS1 was commonly amplified in breast cancer, and high TRPS1 activity was associated with decreased YAP1 activity, leading to decreased frequency of tumor-infiltrating immune cells. 15 Therefore, the present study ... mot halfords invernessWebSep 4, 2024 · Results. PVT1 expression was upregulated in breast cancer tissues and cell lines. In addition, PVT1 silencing inhibited breast cancer cell growth and motility, while … mothakkal pincodeWebTCGA data indicated that the (TRPS1) is a specific gene for breast carcinoma across 31 solid tumor types, including all 4 subtypes of Breast Carcinoma such as ER/PR-positive luminal A and B types, HER2-positive type, and basal-type/TNBC. TRPS1 produced no or little expression in Lung, Pancreatic, Colon, or Gastric Adenocarcinomas, Urothelial, Renal, or … mothakge phadima constructionWebAug 10, 2024 · Involved in breast cancer carcinogenesis and required for breast cancer cell survival Plays a critical role in the development of cartilage, bone and hair follicle ... mini plant oxford visitWebMar 9, 2024 · TRPS1 is amplified/overexpressed in breast cancer and promotes breast carcinogenesis (A) Tissue array analysis for TRPS1 expression (left). ∗∗∗ p < 0.001; two-tailed paired t test. Representative images are shown (right). (B) Western blotting analysis of TRPS1 expression in the indicated cell lines. mini plastic airplanesWebMar 1, 2024 · TRPS1 has been recently demonstrated as a highly sensitive and specific marker for breast carcinomas. To further explore TRPS1's utility in breast carcinoma, we … mothaland bounceWebFeb 15, 2024 · TRPS1 is a GATA-like transcription factor, which functions as a transcriptional repressor or activator, depending on cell type, stage of development, or pathological conditions. Based on this assumption, we explored additional roles of TRPS1 in tumor progression. mini plant watering can