Web13 Oct 2024 · The ditriflato groups in compound 1 could easily be substituted by reaction with neutral Lewis bases, 19-22 leading to mono- or dicationic diboranes. These reactions … Webnoun Chemistry. an atom or atomic group that takes the place of another atom or group present in the molecule of the original compound. adjective having been or capable of …
“Highly Efficient Synthesis of 1- and 5-substituated 1H-Tetrazoles ...
Web2 Nov 2006 · A series of new 4β-5-Fu-substituted 4'-demethylepipodophyllotoxin derivatives were synthesized and evaluated, together with some previously prepared ones, for their cytotoxic activities against four tumor cell lines (HL60, P388, A549 and BEL7402). Three of these compounds exhibited superior in vitro anticancer activity against P388 and A549 … Web24 Jan 2024 · Compound 21, the hydroxyl and difluoro-substituted chalcone analog, exhibits the highest activity. SAR The SAR of compounds 3, 4, 9–15, and 20–23 was explored using the data presented in Tables 1–3 , and reveals that the presence of three methoxy groups on the A ring of the chalcone increases antitubercular activity and that activity decreases in … hoikkala
Substituents and effect of substituents on reactivity and orientation …
WebThey are classified into two and we have discussed below: 1. Nuclear Substituted Compounds In any aromatic compound whenever any substituent or functional group, is directly linked to the benzene ring, it is … WebSolid preparations for oral administration include tablets, pills, powders, granules, capsules, and the like, and these solid preparations may be prepared by mixing the compound of the present invention with at least one excipient, for example, starch, microcrystalline cellulose, sucrose, lactose, low-substituted hydroxypropyl cellulose, hypromellose or the like. Web14 Apr 2024 · The effect of several synthesized substituted benzimidazole compounds were compared to that of the standard drug omeprazole. It was found that compounds R1, R2 and R8 exhibited potent inhibitory activity. The results of molecular docking showed that compound R8 had a maximum binding affinity for H + /K + ATPase of –9.3 kcal/mol. The … hoikka englanniksi