WebMar 15, 2016 · Septins are implicated in microtubule-dependent transport, but their roles are unknown. Here we describe a novel interaction between KIF17, a kinesin 2 family motor, and septin 9 (SEPT9). We show that SEPT9 associates directly with the C-terminal tail of KIF17 and interacts preferentially with the extended cargo-binding conformation of KIF17. WebSeptins are conserved cytoskeletal GTP-binding proteins identified in almost all eukaryotes except higher plants. Mammalian septins comprise 13 family members with either …
瘦素/瘦蛋白（Leptin） - 知乎 - 知乎专栏
http://www.ibp.cas.cn/tpxw_2024/2024tpxw/202404/t20240412_5991850.html WebSeptins are GTP-binding proteins that assemble into higher-order oligomers and filamentous polymers, which associate with cell membranes and the cytoskeleton. In the … chris walker rugby league
Science 肿瘤细胞膜“小泡”招募曲率敏感蛋白促进存活
Web人体内编码septins蛋白的基因有13种,根据序列相似性,分为SEPT2、SEPT3、SEPT6和SEPT7四个亚家族。SEPT7亚家族仅包含Septin7（Sept7）一个成员。Sept7位于染色 … Septins are P-Loop-NTPase proteins that range in weight from 30-65 kDa. Septins are highly conserved between different eukaryotic species. They are composed of a variable-length proline rich N-terminus with a basic phosphoinositide binding motif important for membrane association, a GTP-binding … See more Septins are a group of GTP-binding proteins expressed in all eukaryotic cells except plants. Different septins form protein complexes with each other. These complexes can further assemble into filaments, rings and … See more Since their discovery in S. cerevisiae, septin homologues have been found in other eukaryotic species, including filamentous fungi. Septins in filamentous fungi display a variety of different shapes within single cells, where they control aspects of filamentous See more The septin localized in the mitochondria is called mitochondrial septin (M-septin). It was identified as a CRMP/CRAM-interacting protein in the developing rat brain. See more • Güler GÖ, Mostowy S (Mar 2024). "The septin cytoskeleton: Heteromer composition defines filament function". The Journal of Cell Biology. 222 (3): e202402010–e202402010. doi:10.1083/jcb.202402010. PMID 36821087. • Longtine MS, … See more There are seven different septins in Saccharomyces cerevisiae. Five of those are involved in mitosis, while two (Spr3 and Spr28) are … See more In contrast to septins in yeast, and in contrast to other cytoskeletal components of animals, septins do not form a continuous network in cells, but several dispersed ones in the cytoplasm of the cell cortex. These are integrated with actin bundles and See more The septins were discovered in 1970 by Leland H. Hartwell and colleagues in a screen for temperature-sensitive mutants affecting See more WebFeb 17, 2024 · Septins are regulators of autophagy, especially in yeast and neurons, where an interaction with Atg8 has been observed. SEPT2 can recruit Drp1 to mitochondrial … ghd white platinum styler