Tīmeklis2024. gada 14. dec. · KT-474 is designed to address two skin disorders, hidradenitis suppurativa (HS) and atopic dermatitis (AD). The Phase 1 study was designed to test various doses in healthy volunteers and patients ... Tīmeklis2024. gada 20. maijs · WATERTOWN, Mass., May 20, 2024 (GLOBE NEWSWIRE) -- Kymera Therapeutics, Inc. (NASDAQ: KYMR), a clinical-stage biopharmaceutical …
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Tīmeklis2024. gada 19. janv. · Kymera Therapeutics: IRAK4 (DC 50 = 2.1 nmol/l) PROTAC: Atopic dermatitis: Clinical: Non-Hodgkin's lymphoma: IRAK4 (IC 50 = 0.8 nmol/l) … Tīmeklis2024. gada 24. febr. · IRAK4 Degrader Program (KT-474) KT-474 is a potent, highly selective, orally bioavailable IRAK4 degrader, for the treatment of IL-1R/TLR-driven conditions and diseases with high unmet medical need, including hidradenitis suppurativa (HS), atopic dermatitis (AD), rheumatoid arthritis (RA) and potentially … chase credit card offer match
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TīmeklisKymera is developing the IRAK4 protein degrader KT-474 for the treatment of TLR/IL-1 receptor (IL-1R)-driven inflammatory diseases, including hidradenitis suppurativa (HS) and atopic dermatitis (AD). To understand the role of IRAK4 in HS and AD, we undertook a non-interventional study to evaluate IRAK4 levels in the blood and skin … TīmeklisPF-06650833 in hidradenitis suppurativa. Kymera paid a big price, its stock losing 24%; the Irak-4 project KT-474 is Kymera’s lead, and analysts had been looking to Pfizer’s data to handicap KT-474’s own phase 1 atopic dermatitis/hidradenitis suppurativa update, due in the second half. Then again, Kymera did not help itself, Tīmeklis2024. gada 27. okt. · KT-474 is a highly active and selective, orally bioavailable IRAK4 degrader being developed for the treatment of toll-like receptor (TLR)/interleukin-1 receptor (IL-1R)-driven immune-inflammatory diseases, such as atopic dermatitis, hidradenitis suppurativa, rheumatoid arthritis and potentially other indications. curved arrow sign meaning