Gspt1 knockout mice
WebFeb 4, 2024 · Knockout of TSC1 or TSC2 resulted in enhancement of S6K1 phosphorylation, indicating mTOR hyperactivation ... the antileukemia efficacy of CC-90009 was determined in vivo using xenografting of 35 primary AML samples in NOD.SCID mice (Figure 6B). GSPT1 was quickly degraded in most AML xenografts within 24 hours after … WebMar 21, 2024 · GSPT1 (G1 To S Phase Transition 1) is a Protein Coding gene. Diseases associated with GSPT1 include Duane-Radial Ray Syndrome . Among its related …
Gspt1 knockout mice
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http://us.modelorg.com/portal/article/index/id/11885/post_type/3.html WebDec 9, 2016 · Decreased protein levels of GSPT1 were confirmed in LN229 cells using two different siRNAs for Rac1, as well as from primary astrocytes from Rac1-KO mice (Fig. 5 C). In addition, GSPT1 was increased after treatment with LPS, and the decreased expression of GSPT1 following LPS treatment was observed in Rac1-KD LN229 cells ( Fig. 5 C ).
WebAug 20, 2007 · The eluted GSPT1 protein was used to immunize mice. GSPT1-specific IgG was purified from the GSPT1-specific antiserum using protein G/A beads. The mouse monoclonal anti-FLAG M2 antibody, anti-FLAG ... WebJul 6, 2024 · GSPT1 is also a cereblon client, and we found that BTX306 reduced its expression, as well as that of the GSPT1 interacting protein eRF1, while lenalidomide …
Web10763-1-AP targets eRF3a/GSPT1 in WB, IHC, IF, ELISA applications and shows reactivity with human, mouse, rat samples. PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20°C. Stable for one year after shipment. WebAug 2, 2024 · The present paper demonstrates that miR-625-5p directly inhibits GSPT1, and that knockout of GSPT1 can suppress the proliferation, migration, and invasion of NSCLC cells induced by LINC00511. In this study, animal in vivo studies were carried out through subcutaneous xenograft experiments in nude mice. Our results suggested that silencing …
WebThe ETF1-GSPT1 complex interacts with JMJD4 (PubMed:24486019). Interacts with PABPC1 (By similarity). Interacts with SHFL (PubMed:30682371). By similarity. 3 publications. Binary interactions. Type. Entry 1. Entry 2 Number of experiments Intact; BINARY: P15170: ETF1 P62495: 4: EBI-948993, EBI-750990: BINARY:
WebOct 1, 2024 · Design and structure–activity relationship of novel GSPT1 degraders with benzotriazinone scaffold (TD-105) • 34f (TD-522) exhibit strong anti-proliferative effect in both KG-1 AML and TMD-8 DLBCL cell lines.. 34f effectively induce GSPT1 degradation with DC 50 of 0.269 nM in KG-1 cells.. 34f effectively suppress TMD-driven tumor growth … how was your childhoodWebNov 13, 2024 · Background: CC-90009 is a cereblon (CRBN) E3 ligase modulator (CELMoD) and a first-in-class small molecule that drives the binding of a novel target protein, G1 to S phase transition 1 (GSPT1), to CRBN, resulting in the proteasome-dependent degradation of GSPT1. GSPT1 plays a central role in mRNA translation, and … how was your day at school in spanishWebOn Dec 16, 2024, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC … how was your day darling faceWebATCC has the world’s largest and most extensive product catalog of human and animal cell lines for research purposes. The cell biology collection includes more than 4,000 … how was your chinese new yearWebThe Gspt1 gene (NCBI Reference Sequence: NM_146066 ; Ensembl: ENSMUSG00000062203 ) is located on mouse chromosome 16. Fifteen exons are … how was your day in germanhow was your day diversity trainingWebTomcat® Super Hold Glue Traps Mouse Size are the pesticide-free, non-toxic way to effectively control mice. Effectively captures mice and other rodents or pests. Also traps … how was your day alternatives