WebJan 4, 2024 · Cryptotanshinone is a natural compound extracted from the root of Salvia miltiorrhiza Bunge that shows antitumor activities. Cryptotanshinone inhibits STAT3 with an IC50 of 4.6 μM. Properties Articles 39 Spectrum Names Cryptotanshinone Biological Activity Chemical & Physical Properties MSDS Cryptotanshinone MSDS (Chinese) Safety … WebCryptotanshinone (CTS) is a herbal medicine and has been identified as an anti-inflammatory and anti-oxidative drug. Methods: In vitro assays, including the cell proliferation assay, colony formation assay, Western blot analysis, transwell migration/invasion assays, and cell scratch assay were used to explore the biological …
Frontiers Novel STAT3 Inhibitors Targeting STAT3 …
WebCryptotanshinone can induce the apoptosis of cancer cells by inhibiting PI3K/AKT, STAT3 signaling pathways, as well as transcription of MMP14, STAT3, and Nrf2 genes. The arrow represents the upregulation, and the T area represents the downregulation. Conclusion Webjak-stat信号通路,能快速将受体接收到的膜外刺激信号传导入细胞内,进而调控下游相关基因的表达,实现受体-jak-stat-靶基因激活的高效信号传导反应.细胞活素或生长因子在细胞表面与其受体结合,致使jak2激酶c端的酪氨酸残基磷酸化,进而招募stat3,致其磷酸 ... frackweste
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WebMar 2, 2024 · 基于此,本研究结果发现,脑心通胶囊中阿魏酸(2.5 μg/mL)可显著下调细胞中STAT3、Akt、ERK的mRNA表达,丹酚酸B(50 μmol/L)可显著下调细胞中JAK2和STAT3的mRNA表达,芒柄花素(25 μmol/L)和黄芪甲苷(2.5 μmol/L)分别可显著下调细胞中JAK2和Akt的mRNA表达;而部分有效 ... WebSep 29, 2024 · Pyrotinib specifically targeted TSC2-deficient cells, inhibited tumor cell viability and induced apoptosis through EGFR-STAT3/CD24 Loop in vivo and in vitro. Thus, pyrotinib may be a promising new therapeutic drug for TSC treatment. ... Similarly, cryptotanshinone induced significant early and late apoptosis in TSC2-deficient cells, but … WebApr 9, 2024 · Cryptotanshinone (CTN) has shown its neuroprotective and anti-inflammatory qualities in non-genetic mouse model of Alzheimer’s disease. According to bioinformatics analysis, CTN and Signal Transducer and Activator of Transcription 3 (STAT3) may interact to form a drug-target network. frackville pa to waymart pa