Collagen-induced arthritis model
WebMethods: A rat collagen-induced arthritis (CIA) model was established to investigate the mechanism of Naru-3. Rats were treated with Naru-3, Etanercept (ETN), and sodium carboxymethylcellulose (CMC) for four weeks. After treatment was terminated, paw thickness, ankle diameter, and arthritis index (AI) were scored. WebFinally, we verified the effects of koumine on macrophage polarization and the PI3K/AKT signaling pathway by decreasing M1 macrophage marker levels and increasing M2 macrophage marker levels in collagen-induced arthritis (CIA) mice to comprehensively elucidate the anti-RA mechanism of koumine and provide a theoretical and scientific …
Collagen-induced arthritis model
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WebAug 16, 2024 · Collagen-induced arthritis (CIA) is the gold standard animal model of RA and forms the genetic and molecular background of the majority of genetically modified RA strains in C57BL/6 mice. CIA is characterized by T-cell and cytokine-dependent sustained responses to exogenous type II collagen that causes recruitment of macrophages, … WebJul 2, 2024 · Mice and collagen-induced arthritis (CIA) model. PR-flox mice were obtained from Baylor College of Medicine (Houston, TX, USA). A targeting vector designed to replace part of exon 2 of the PR gene with a selectable marker was employed to create a strain of mice carrying a conditional null PR allele [].Prx1-Cre mice were purchased from the …
WebJan 19, 2024 · The Antibody Ameliorated Collagen-Induced Arthritis in Cynomolgus Monkey. In order to assess the efficacy of the antibody, we next examined whether HZ-0408b can ameliorate arthritis with a monkey collagen-induced arthritis (CIA) model. CIA was induced by immunization of bovine type II collagen in female cynomolgus monkeys . WebThe induced arthritis models include the collagen-induced arthritis (CIA), collagen-antibody-induced arthritis (CAIA), and antigen (Ag)-induced arthritis (AIA) models. …
WebMasayuki Mizui, George C. Tsokos, in The Autoimmune Diseases (Sixth Edition), 2024. Collagen Antibody–Induced Arthritis Model. Collagen antibody –induced arthritis (CAIA) is induced by injection of specific monoclonal CII antibodies (Holmdahl et al., 1986).The model was developed based on the findings that serum from arthritic mice or … WebInduced arthritis models Collagen-induced arthritis. Collagen-induced arthritis (CIA) shares many similarities with human RA. Two characteristics of the CIA model – breach of tolerance and generation of auto-antibodies toward self and collagen – make CIA the gold standard in vivo model for RA studies.
WebMar 31, 2024 · The altering effect of circRNA_17725 on macrophages in vivo was evaluated using collagen-induced arthritis (CIA) mouse model. circRNA_17725 was demonstrated to be downregulated in peripheral blood mononuclear cells and CD14 + monocytes from RA cases in contrast to healthy controls. The negative association between circRNA_17725 …
WebCollagen-induced arthritis (CIA) in mice is an experimental model of autoimmune diseases induced by immunization with type II collagen (CII) (Courtenay et al., 1980). … pain in shoulder blade down armWebJul 2, 2024 · Mice and collagen-induced arthritis (CIA) model. PR-flox mice were obtained from Baylor College of Medicine (Houston, TX, USA). A targeting vector designed to … subhomoy bhattacharjeeWebJul 24, 2024 · CD163 deficiency strongly enhances disease severity in experimental CIA. Mice immunized with chicken type II collagen in adjuvant induced a modest arthritis response in normal C57/BL6 mice as ... pain in shoulder blades on treadmillWebChondrex, Inc. has manufactured purified collagen and both Freund's complete and incomplete adjuvants for use in the Collagen Induced Arthritis (CIA) model for over 20 years. With hundreds of published studies using our collagen and adjuvants, you can trust Chondrex to provide high quality reagents for your preclinical studies. subhomita best songsWebJan 1, 2009 · Abstract. Collagen-induced arthritis (CIA) in mice is an animal model for rheumatoid arthritis (RA) and can be induced in DBA/1 and C57BL/6 mice using different protocols. The CIA model can be used to unravel mechanisms involved in the development of arthritis and is frequently used to study the effect of new therapeutics. pain in shoulder blade area backWebMay 17, 2007 · The collagen-induced arthritis (CIA) mouse model is the most commonly studied autoimmune model of rheumatoid arthritis. Autoimmune arthritis is induced in … pain in shoulder blade area and neckWebObjective: The present study compared three models of induction of osteoarthritis (OA) and rheumatoid arthritis (RA) in the temporomandibular joint (TMJ) of rats. Design: The induction method was by injection of complete Freund's adjuvant (CFA) + type II bovine collagen (CII). Twenty-four adult male rats were divided into four groups (n = 6): G1: … pain in shoulder elbow and forearm